| Date | Location | Result | |
| Nov 20, 2021 | South Euclid, Ohio | Notre Dame (OH) 33, Slippery Rock 25 | Box score |
| Nov 13, 2021 | Kutztown, Pa. | Kutztown 38, Slippery Rock 32 | Box score |
| Nov 06, 2021 | Slippery Rock, Pa. | Slippery Rock 38, California (Pa.) 26 | Box score |
| Oct 30, 2021 | Erie, Pa. | Slippery Rock 63, Gannon 21 | Box score |
| Oct 23, 2021 | Erie, PA | Slippery Rock 20, Mercyhurst 17 | Box score |
| Oct 16, 2021 | Slippery Rock, Pa. | Indiana (Pa.) 48, Slippery Rock 21 | Box score |
| Oct 09, 2021 | Edinboro, Pa. | Slippery Rock 49, Edinboro 13 | Box score |
| Oct 02, 2021 | Slippery Rock, Pa. | Slippery Rock 75, Clarion 0 | Box score |
| Sep 25, 2021 | Greensburg, PA | Slippery Rock 41, Seton Hill 17 | Box score |
| Sep 18, 2021 | Slippery Rock, Pa. | Slippery Rock 57, Lock Haven 7 | Box score |
| Sep 11, 2021 | Slippery Rock, Pa. | Slippery Rock 22, East Stroudsburg 7 | Box score |
| Sep 02, 2021 | Detroit, Michigan | Slippery Rock 24, Wayne St. (MI) 21 | Box score |